Research Publications

EOLIA Trial

Respiratory Failure Position Paper

IDEA Study

LIFEGARDS Study

Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS

ECMO Survey

Bayesian Analyis of EOLIA REST

TRACHMO

Core Outcome Measures Delphi Study

ETHOS Survey

Anticoagulation

DRIVE P

SUPERNOVA II

Cardiac Failure Position Paper

SUPERNOVA

ECMO PT: Early Mobilisation in ECMO

The perceived barriers and facilitators to implementation of ECMO services in acute hospitals.

Research in Extracorporeal Life Support: A Call to Action

ECCO2R Position paper

Venoarterial ECMO to rescue sepsis-induced cardiogenic shock

Sub30

2023

Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID‑19 severe ARDS: an international Delphi study

Rabie, A. A., Elhazmi, A., Azzam, M. H., Abdelbary, A., Labib, A., Combes, A., … & Bartlett, R. (2023). Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID-19 severe ARDS: an international Delphi study. Annals of Intensive Care, 13(1), 1-12.

PROTECMO

Martucci, G., Schmidt, M., Agerstrand, C., Tabatabai, A., Tuzzolino, F., Giani, M., … & Maclaren, G. (2023). Transfusion practice in patients receiving VV ECMO (PROTECMO): A prospective, multicentre, observational study. The Lancet Respiratory Medicine, 11(3), 245-255.

2022

EXCEL

Hodgson, C. L., Higgins, A. M., Bailey, M. J., Anderson, S., Bernard, S., Fulcher, B. J., … & Sheldrake, J. S. (2022). Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study. The Lancet Respiratory Medicine, 10(11), 1038-1048.

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation: A Randomized Clinical Trial

Levy, B., Girerd, N., Amour, J., Besnier, E., Nesseler, N., Helms, J., … & Kindo, M. (2022). Effect of moderate hypothermia vs normothermia on 30-day mortality in patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation: a randomized clinical trial. JAMA, 327(5), 442-453.

MORE-PT

Abrams, D., Madahar, P., Eckhardt, C. M., Short, B., Yip, N. H., Parekh, M., … & Brodie, D. (2022). Early mobilization during extracorporeal membrane oxygenation for cardiopulmonary failure in adults: factors associated with intensity of treatment. Annals of the American Thoracic Society, 19(1), 90-98.

2021

REST

McNamee JJ, Gillies MA, Barrett NA, et al. Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial. JAMA. 2021;326(11):1013–1023. doi:10.1001/jama.2021.13374.

TRACHMO

Schmidt, M., Fisser, C., Martucci, G. et al. Tracheostomy management in patients with severe acute respiratory distress syndrome receiving extracorporeal membrane oxygenation: an International Multicenter Retrospective Study. Crit Care 25, 238 (2021). https://doi.org/10.1186/s13054-021-03649-8.

2020

Sub30: Protocol for the Sub30 feasibility study of a pre-hospital Extracorporeal membrane oxygenation (ECMO) capable advanced resuscitation team at achieving blood flow within 30 min in patients with refractory out-of-hospital cardiac arrest

Singer, B., Reynolds, J. C., Davies, G. E., Wrigley, F., Whitbread, M., Faulkner, M., O’Brien, B., Proudfoot, A. G., Mathur, A., Evens, T., Field, J., Monk, V., Finney, S. J., & International ECMO Network (ECMONet) (2020). Sub30: Protocol for the Sub30 feasibility study of a pre-hospital Extracorporeal membrane oxygenation (ECMO) capable advanced resuscitation team at achieving blood flow within 30 ​min in patients with refractory out-of-hospital cardiac arrest. Resuscitation plus, 4, 100029. https://doi.org/10.1016/j.resplu.2020.100029

Drive P Study

Del Sorbo L, Goffi A, Tomlinson G, Pettenuzzo T, Facchin F, Vendramin A, Goligher EC, Cypel M, Slutsky AS, Keshavjee S, Ferguson ND, Fan E; International ECMO Network (ECMONet). Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study. Crit Care Med. 2020 Oct 12. doi: 10.1097/CCM.0000000000004637.

ECMO Survey

Linke NJ, Fulcher BJ, Engeler DM, Anderson S, Bailey MJ, Bernard S, Board JV, Brodie D, Buhr H, Burrell AJC, Cooper DJ, Fan E, Fraser JF, Gattas DJ, Higgins AM, Hopper IK, Huckson S, Litton E, McGuinness SP, Nair P, Orford N, Parke RL, Pellegrino VA, Pilcher DV, Sheldrake J, Reddi BAJ, Stub D, Trapani TV, Udy AA, Hodgson CL; EXCEL Investigators. A survey of extracorporeal membrane oxygenation practice in 23 Australian adult intensive care units. Crit Care Resusc. 2020 Jun;22(2):166-170. PMID: 32389109.

The perceived barriers and facilitators to implementation of ECMO services in acute hospitals.

Fulcher BJ, Nicholson AJ, Linke NJ, Berkovic D, Hodgson CL; EXCEL Study Investigators and the International ECMO Network. The perceived barriers and facilitators to implementation of ECMO services in acute hospitals. Intensive Care Med. 2020 Jul 23. doi: 10.1007/s00134-020-06187-z. Epub ahead of print. PMID: 32705292.

ECMO-PT: Early Mobilisation during ECMO was safe and feasible: a pilot randomised control trial

ECMO-PT Study Investigators; International ECMO Network. Early mobilisation during extracorporeal membrane oxygenation was safe and feasible: a pilot randomised controlled trial. Intensive Care Med. 2020 May;46(5):1057-1059. doi: 10.1007/s00134-020-05994-8. Epub 2020 Mar 16. PMID: 32179935.

Combined Mesenchymal Stromal Cell Therapy and ECMO in ARDS

Millar JE, Bartnikowski N, Passmore MR, Obonyo NG, Malfertheiner MV, von Bahr V, Redd MA, See Hoe L, Ki KK, Pedersen S, Boyle AJ, Baillie JK, Shekar K, Palpant N, Suen JY, Matthay MA, McAuley DF, Fraser JF. Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep. Am J Respir Crit Care Med. 2020 Aug 1;202(3):383-392. doi: 10.1164/rccm.201911-2143OC. PMID: 32293914; PMCID: PMC7397785.

Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock

Bréchot N, Hajage D, Kimmoun A, Demiselle J, Agerstrand C, Montero S, Schmidt M, Luyt CE, Lebreton G, Hékimian G, Flecher E, Zogheib E, Levy B, Slutsky AS, Brodie D, Asfar P, Combes A; International ECMO Network. Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: a retrospective, multicentre, international cohort study. Lancet. 2020 Aug 22;396(10250):545-552. doi: 10.1016/S0140-6736(20)30733-9. PMID: 32828186.

Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries

Bull T, Corley A, Lye I, Spooner AJ, Fraser JF (2019) Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries. PLoS ONE 14(12): e0227248. https://doi.org/10.1371/journal.pone.0227248.

2019

Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design

Goligher, E.C., Combes, A., Brodie, D. et al. Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design. Intensive Care Med 45, 1219–1230 (2019). https://doi.org/10.1007/s00134-019-05708-9

Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice

Abrams D, Schmidt M, Pham T, Beitler JR, Fan E, Goligher EC, McNamee JJ, Patroniti N, Wilcox ME, Combes A, Ferguson ND, McAuley DF, Pesenti A, Quintel M, Fraser J, Hodgson CL, Hough CL, Mercat A, Mueller T, Pellegrino V, Ranieri VM, Rowan K, Shekar K, Brochard L, Brodie D; International ECMO Network (ECMONet). Mechanical Ventilation for ARDS During Extracorporeal Life Support: Research and Practice. Am J Respir Crit Care Med. 2019 Nov 14. doi: 10.1164/rccm.201907-1283CI.

Core Outcome Measures – Delphi Study

Core Outcome Measures for Research in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation for Acute Respiratory or
Cardiac Failure: An International, Multidisciplinary, Modified Delphi Consensus Study

Hodgson CL, Burrell AJC, Engeler DM, Pellegrino VA, Brodie D, Fan E; On behalf of the International ECMO Network. Core outcome measures for research in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) for acute respiratory failure or cardiac failure: an international, multidisciplinary, modified Delphi consensus study. Crit Care Med 2019;53:98-106.

ETHOS

Practice Patterns and Ethical Considerations in the Management of Venovenous Extracorporeal Membrane Oxygenation Patients: An International Survey

Abrams, Darryl, MD; Pham, Tài MD; Burns, Karen E. A. MD; Combes, Alain MD; Curtis, J. Randall MD; Mueller, Thomas MD; Prager, Kenneth M. MD; Serra, Alexis MD; Slutsky, Arthur S. MD; Brodie, Daniel MD; Schmidt, Matthieu MD on behalf of the International ECMO Network (ECMONet). Critical Care Medicine. 2019 July 25: Volume Online First.

ETHOS is a prospective, multicenter web-based survey in response to a clinical case vignette. The objectives of the study are to depict practice variation regarding ECMO use, maintenance, withdrawal and determination of futility in severe ARDS in an international cohort of ECMO physicians and identify which physician and hospital-centered factors are related.

VA ECMO Systematic Review

Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications

Burrell AJC, Bennett V, Serra AL, Pellegrino VA, Romero L, Fan E, Brodie D, Cooper DJ, Kaye DM, Fraser JF, Hodgson CL; International ECMO Network (ECMONet). Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications. J Crit Care. 2019 May 24;53:32-37. [Epub ahead of print]

LIFEGARDS

Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort

Schmidt M, Pham T, Arcadipane A, Agerstrand C, Ohshimo S, Pellegrino V, Vuylsteke A, Guervilly C, McGuinness S, Pierard S, Breeding J, Stewart C, Ching SSW, Camuso JM, Stephens RS, King B, Herr D, Schultz MJ, Neuville M, Zogheib E, Mira JP, Rozé H, Pierrot M, Tobin A, Hodgson C, Chevret S, Brodie D, Combes A; International ECMO Network (ECMONet), and the LIFEGARDS Study Group. Mechanical Ventilation Management during ECMO for ARDS: An International Multicenter Prospective Cohort. Am J Respir Crit Care Med. 2019 May 30.

Anticoagulation

Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial

Aubron C, McQuilten Z, Bailey M, Board J, Buhr H, Cartwright B, Dennis M, Hodgson C, Forrest P, McIlroy D, Murphy D, Murray L, Pellegrino V, Pilcher D, Sheldrake J, Tran H, Vallance S, Cooper DJ; endorsed by the International ECMO Network (ECMONet). Low-Dose Versus Therapeutic Anticoagulation in Patients on Extracorporeal Membrane Oxygenation: A Pilot Randomized Trial.  Crit Care Med.  2019 Jul;47(7):e563-e571.

SUPERNOVA

Combes A, Fanelli V, Pham T, Ranieri VM; European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators. Feasibility and safety of extracorporeal CO2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study. Intensive Care Med 2019; online Feb 21. 

HYPO-ECMO

Jacquot, A., Lepage, X., Merckle, L., Girerd, N., & Levy, B. (2019). Protocol for a multicentre randomised controlled trial evaluating the effects of moderate hypothermia versus normothermia on mortality in patients with refractory cardiogenic shock rescued by venoarterial extracorporeal membrane oxygenation (VA-ECMO)(HYPO-ECMO study). BMJ open, 9(10), e031697.

2018

EOLIA

Combes A, Hajage D, Capellier G, Demoule A, Lavoué S, Guervilly C, Da Silva D, Zafrani L, Tirot P, Veber B, Maury E, Levy B, Cohen Y, Richard C, Kalfon P, Bouadma L, Mehdaoui H, Beduneau G, Lebreton G, Brochard L, Ferguson ND, Fan E, Slutsky AS, Brodie D, Mercat A; EOLIA Trial Group, REVA, and ECMONet. N Engl J Med. 2018 May 24;378(21):1965-1975. 

EOLIA is a multicenter, international, randomized, controlled trial run by the REVA network and endorsed by the International ECMO Network. The study hypothesizes that ECMO, instituted early after the diagnosis of very severe ARDS (P:F < 80), would lower the morbidity and mortality associated with this syndrome.

Bayesian Analysis of EOLIA

Goligher EC, Tomlinson G, Hajage D, et al. Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome and Posterior Probability of Mortality Benefit in a Post Hoc Bayesian Analysis of a Randomized Clinical Trial. JAMA. 2018;320(21):2251–2259. doi:10.1001/jama.2018.14276.

Cardiac Failure Position Paper

Abrams et al. Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med 2018;epublished February 15th.

This position paper represents the expert opinion of an international group of physicians, ECMO specialists and allied health-care workers who have expertise relevant to the mechanical circulatory support used to treat patients with severe cardiac failure. The aim of this paper is to provide clinicians, ECMO center directors and coordinators, hospital administrators, healthcare organizations, and regional, national, and international policy makers a consensus approach to the organization of ECMO programs for cardiac failure and cardiac arrest in adults.

Research in Extracorporeal Life Support: A Call to Action

Daniel Brodie, Jean-Louis Vincent, Laurent J. Brochard, Alain Combes, Niall D. Ferguson, Carol L. Hodgson, John G. Laffey, Alain Mercat, Antonio Pesenti, Michael Quintel, Arthur S. Slutsky, V. Marco Ranieri, Jan Bakker, Michael Broome, Jacques Creteur, Daniel De Backer, Luciano Gattinoi, Roberto Lorusso, Stefano Nava, Laurent Papazian, Peter Rimensberger, Claudio Ronco, Robert Sladen, Thomas Staudinger, Fabio Taccone. Research in Extracorporeal Life Support: A Call to Action. Chest. Volume 153, Issue 4. 2018. Pages 788-791.

ECCO2R Position paper

Boyle AJ, Sklar MC, McNamee JJ, et al. Extracorporeal carbon dioxide removal for lowering the risk of mechanical ventilation: research questions and clinical potential for the future. Lancet Respir Med. 2018;6:874–84.

This position paper represents the expert opinion of an international group of physicians and allied health-care professionals who have expertise relevant to the use of extracorporeal CO2 removal (ECCO2R) in clinical trials and practice. It will provide clinicians, ECCO2R providers, policy makers and clinical researchers with a concise summary of the technology and its use in research and clinical practice. This information informs a summary of recommendations for the use of ECCO2R and areas where there is a requirement for further study.

IDEA Study

Schmidt M, Schellongowski P, Patroniti N, Taccone FS, Reis Miranda D, Reuter J, Prodanovic H, Pierrot M, Dorget A, Park S, Balik M, Demoule A, Crippa IA, Mercat A, Wohlfarth P, Sonneville R, Combes A; International ECMO Network (ECMONet), the REVA Research Network and the IDEA Study Group. Six-month Outcome of Immunocompromised Severe ARDS Patients Rescued by ECMO. An International Multicenter Retrospective Study. Am J Respir Crit Care Med. 2018 Jan 3. doi: 10.1164/rccm.201708-1761OC.

This study provides, for the first time, detailed descriptive data on the characteristics, the complication and the outcome of adult’s immunocompromised patients receiving ECMO for ARDS. 

2014

Respiratory Failure Position Paper

Combes et al. Position Paper for the Organization of Extracorporeal Membrane Oxygenation Programs for Acute Respiratory Failure in Adult Patients. Am J Respir Crit Care Med 2014;190(5):488-496.

The aim of this paper is to provide physicians, ECMO center directors and coordinators, hospital directors, health care organizations, regional, national and international policy makers a description of the optimal approach to organizing ECMO programs for acute respiratory failure in adult patients. Importantly, this will help ensure that ECMO is delivered safely and proficiently, such that future observational and randomized clinical trials assessing this technique may be performed by experienced centers under homogeneous and optimal conditions.