Publications
2025
Death and new disability following bleeding complications during venoarterial extracorporeal membrane oxygenation. A prospective cohort study from the EXCEL registry.
Alastair Brown, Mark Dennis, Nivedita Rattan, Vinodh Bhagyalakshmi Nanjayya, Aidan Burrell, Ary Serpa Neto, Carol Hodgson for the EXCEL Study Investigators and the International ECMO Network
Bleeding events are common during the provision of Venoarterial ECMO (VA ECMO). Previous observational has suggested that these bleeding events are associated with an increased risk of in-hospital mortality however data on long term mortality and functional outcomes are lacking.
Liberal or restrictive transfusion for veno-arterial extracorporeal membrane oxygenation patients: a target trial emulation using the OBLEX study data.
Thao LTP, Buscher H, Nguyen TL, Martucci G, Gratz J, Trummer G, Schmidt M, Gautier M, Serra A, Takeda K, Pooth JS, Rahn K, Geismann F, Lubnow M, Retter A, Nair P, Vlok R, Siriwardena M, Winearls J, Walsham J, Gattas D, Aneman A, Fulcher B, Newman S, Reynolds C, Arcadipane A, Shekar K, Hodgson C, Pellegrino V, Mueller T, Brodie D, McQuilten Z; International ECMO Network (ECMONet).
This target trial emulation study suggests that a liberal transfusion threshold may provide a modest survival benefit during the early course of VA-ECMO, but no benefit afterwards. Prospective studies are needed to confirm these findings, assess clinical adoption, and investigate underlying mechanism.
Long-term outcomes and quality of life have been identified as core patient-centered outcomes for venoarterial extracorporeal membrane oxygenation (VA-ECMO) research. The aim of this study is to investigate the incidence of death or new disability at 12 months after the initiation of VA-ECMO.
Ary Serpa Neto, Alisa M Higgins, Michael J Bailey, Shannah Anderson, Stephen Bernard, Bentley J Fulcher, Annalie Jones, Natalie J Linke, Jasmin V Board, Daniel Brodie, Heidi Buhr, Aidan J C Burrell, D James Cooper, Eddy Fan, John F Fraser, David J Gattas, Ingrid K Hopper, Sue Huckson, Edward Litton, Shay P McGuinness, Priya Nair, Neil Orford, Rachael L Parke, Vincent A Pellegrino, David V Pilcher, Craig Dicker, Benjamin A J Reddi, Dion Stub, Tony V Trapani, Andrew A Udy, Carol L Hodgson; EXCEL Study Investigators on behalf of the International ECMO Network (ECMONet).
Long-term outcomes and quality of life have been identified as core patient-centered outcomes for venoarterial extracorporeal membrane oxygenation (VA-ECMO) research. The aim of this study is to investigate the incidence of death or new disability at 12 months after the initiation of VA-ECMO.
2024
Anticoagulation and Bleeding during Veno-Venous Extracorporeal Membrane Oxygenation: Insights from the PROTECMO Study
Martucci G, Giani M, Schmidt M, Tanaka K, Tabatabai A, Tuzzolino F, et al.
Hypothermia in patients with cardiac arrest prior to ECMO-VA: Insight from the HYPO-ECMO trial
Levy B, Girerd N, Duarte K, Antoine M-L, Monzo L, Ouattara A. et al.
Serial daily lactate levels association with 30-day outcome in cardiogenic shock patients treated with VA-ECMO: a post-hoc analysis of the HYPO-ECMO study
Levy B, Girerd N, Baudry G, Duarte K, Cuau S, Bakker J, et al.
Extracorporeal Carbon Dioxide Removal to Avoid Invasive Ventilation During Exacerbations of Chronic Obstructive Pulmonary Disease: VENT-AVOID Trial - A Randomized Clinical Trial
Duggal A, Conrad SA, Barrett NA, Saad M, Cheema T, Pannu S, et al.
Conservative or Liberal Oxygen Targets in Patients on VA ECMO
Burrell AJC, Bailey MJ, Bellomo R, Buscher H, Eastwood G, Forrest P, et al.
Hospital-level volume in ECMO cases and death or disability at 6 months
Ertugrul AD, Neto AS, Fulcher BJ, Charles-Nelson A, Bailey M, Burrell AJC, et al.
2023
Expert consensus statement on venovenous extracorporeal membrane oxygenation ECMO for COVID‑19 severe ARDS: an international Delphi study
Ahmed A Rabie, Alyaa Elhazmi, Mohamed H Azzam, Akram Abdelbary, Ahmed Labib, Alain Combes, Bishoy Zakhary, Graeme MacLaren, Ryan P Barbaro, Giles J Peek, Marta Velia Antonini, Kiran Shekar, Abdulrahman Al‐Fares, Pranay Oza, Yatin Mehta, Huda Alfoudri, Kollengode Ramanathan, Mark Ogino, Lakshmi Raman, Matthew Paden, Daniel Brodie, Robert Bartlett
The high-quality evidence on managing COVID-19 patients requiring extracorporeal membrane oxygenation (ECMO) support is insufficient. Furthermore, there is little consensus on allocating ECMO resources when scarce.
Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial
James J. McNamee, MB, ChB; Michael A. Gillies, MD; Nicholas A. Barrett, MB, ChB; Gavin D. Perkins, MD; William Tunnicliffe, MSc; Duncan Young, DM; Andrew Bentley, MD; David A. Harrison, PhD; Daniel Brodie, MD; Andrew J. Boyle, MB, ChB; Jonathan E. Millar, PhD; Tamas Szakmany, PhD; Jonathan Bannard-Smith, MB, ChB; Redmond P. Tully, MBBS; Ashley Agus, PhD; Clíona McDowell, MSc; Colette Jackson; Daniel F. McAuley, MD; for the REST Investigators
In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.
Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study
Martucci, G., Schmidt, M., Agerstrand, C., Tabatabai, A., Tuzzolino, F., Giani, M., … & Maclaren, G.
In patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) packed red blood cell (PRBC) transfusion thresholds are usually higher than in other patients who are critically ill. Available guidelines suggest a restrictive approach, but do not provide specific recommendations on the topic. The main aim of this study was, in a short timeframe, to describe the actual values of haemoglobin and the rate and the thresholds for transfusion of PRBC during VV ECMO.
Extracorporeal membrane oxygenation in adults receiving haematopoietic cell transplantation: an international expert statement
Matteo Di Nardo, Graeme MacLaren, Peter Schellongowski, Elie Azoulay, Amy E DeZern, Cristina Gutierrez, Massimo Antonelli, Marta V Antonini, Gernot Beutel, Alain Combes, Rodrigo Diaz, Ibrahim Fawzy Hassan, Jo-Anne Fowles, In-Seok Jeong, Matthias Kochanek, Tobias Liebregts, Catherina Lueck, Karen Moody, Jessica A Moore, Laveena Munshi, Matthew Paden, Frédéric Pène, Kathryn Puxty, Matthieu Schmidt, Dawid Staudacher, Thomas Staudinger, Joachim Stemmler, R Scott Stephens, Lisa Vande Vusse, Philipp Wohlfarth, Roberto Lorusso, Antonio Amodeo, Kris M Mahadeo, Daniel Brodie; European Society of Intensive Care Medicine, the International ECMO Network, and the Extracorporeal Life Support Organization.
Combined advances in haematopoietic cell transplantation (HCT) and intensive care management have improved the survival of patients with haematological malignancies admitted to the intensive care unit. In cases of refractory respiratory failure or refractory cardiac failure, these advances have led to a renewed interest in advanced life support therapies, such as extracorporeal membrane oxygenation (ECMO), previously considered inappropriate for these patients due to their poor prognosis.
2022
Hodgson, C. L., Higgins, A. M., Bailey, M. J., Anderson, S., Bernard, S., Fulcher, B. J., … & Sheldrake, J. S. (2022). Incidence of death or disability at 6 months after extracorporeal membrane oxygenation in Australia: a prospective, multicentre, registry-embedded cohort study. The Lancet Respiratory Medicine, 10(11), 1038-1048.
Levy, B., Girerd, N., Amour, J., Besnier, E., Nesseler, N., Helms, J., … & Kindo, M. (2022). Effect of moderate hypothermia vs normothermia on 30-day mortality in patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenation: a randomized clinical trial. JAMA, 327(5), 442-453.
Abrams, D., Madahar, P., Eckhardt, C. M., Short, B., Yip, N. H., Parekh, M., … & Brodie, D. (2022). Early mobilization during extracorporeal membrane oxygenation for cardiopulmonary failure in adults: factors associated with intensity of treatment. Annals of the American Thoracic Society, 19(1), 90-98.